Chlorhexidine digluconate

Research use only, not for human use.

Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.

Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis.

Cell Cytotoxicity Assay Cell Line:Chinese hamster ovary cells Concentration:0.00001%, 0.00005%, 0.0001%, 0.0005% Incubation Time:1, 2, 4 h Result:Demonstrated a cytotoxic effect on CHO cells.Apoptosis Analysis Cell Line:Chinese hamster ovary cells Concentration:0.00005%, 0.0001%, 0.0005% Incubation Time:1 h Result:After a 1 hour treatment, the amount of cell apoptosis was about 1.62%, 5.51%, and 5.47%, respectively. The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively.

Model:Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g)Dosage:Chlorhexidine gluconate 0.05% and 0.025% Administration:One-time intraperitoneal injection Result:With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.

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Apoptosis

Apoptosis

Apoptosis | Antibiotic

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18472-51-0

897.76

C34H54Cl2N10O14

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (111.39 mM; Ultrasonic) DMSO : ≥ 38 mg/mL (42.33 mM)

ClC(C=C1)=CC=C1NC(NC(NCCCCCCNC(NC(NC2=CC=C(C=C2)Cl)=N)=N)=N)=N.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years